Ashitaka, a prince of the rapidly vanishing Emishi tribe, is plagued by a curse from a demonized boar deity and embarks on a journey to the west in search of a cure. On his journey, he meets San, a young and determined woman who is fighting to preserve the forest, and Lady Eboshi, who aims to destroy it. With the fate of the land hanging in balance, Ashitaka must navigate the conflicting interests of these two forces and find a way to bring harmony to the situation.